Until recently, cardiotoxicity in the setting of a malignant disease was attributed solely to the detrimental effects of chemo‐ and/or radio‐therapy to the heart. On this account, the focus was on the evaluation of well‐established cardiac biomarkers for the early detection of myocardial damage. Currently, this view has been revised. Cardiotoxicity is not restricted to a single organ but instead affects the endothelium as a whole. Indeed, it has come into light that not only cancer therapy but also malignant cells (...) per se can impair the cardiovascular system, through a paracrine and endocrine mode of action. Even more intriguingly, a clear interplay between molecular pathways involved in cancer and cardiovascular disease has become prevalent, suggesting a common nominator that governs the pathophysiology of these two entities. Taken together, our strategy in the quest of novel biomarkers in the emerging field of cardio‐oncology should be critically reshaped. (shrink)

Civil Protection and disaster risk specific agencies legally responsible to enhance individual and community resilience, still utilize in their risk and crisis communication efforts, the “deficit model” even though its basic assumption and approach have been criticized. Recent studies indicate that information seeking behavior is not necessarily a measure of enhanced individual preparedness. A qualitative change from “blindly” following directions to practicing emergency planning and becoming your own disaster risk manager is required. For pandemics, the challenge is even more complicated (...) due to their unique characteristics. Community based exercises, a framework concept encompassing a variety of interactive activities, have recently started being utilized to develop resilience amongst citizens. Existing models of resilience can pinpoint to the required knowledge, skills and attitude. Research in the factors influencing behavioral change could offer new understanding of the interplay between cognitive and demographic drivers/factors of resilience. Such knowledge could be utilized for setting targeted objectives, developing appropriate activities and the corresponding training for the CBEx facilitators. Despite the importance of preparation, the current covid-19 crisis indicates that high levels of adaptive resilience can be displayed even in the absence of any risk communication effort beforehand by utilizing a pre-existing collective understanding of the system situation. (shrink)

Hegel's teachings on the state, law, and society constitute a philosophy of law and were developed by him as the philosophy of the objective spirit. In addition to providing a basis for historically concrete views on political matters, the Hegelian philosophy of law, as an application of dialectics to a specific realm of subject matter in societal, governmental, and political-legal phenomena, contains the logic of that realm of subject matter. The independent meaning of this domain of research transforms logic and (...) gives it politically significant features despite the conscious Hegelian attitude of "logicizing" politics. This is clearly manifested in the political and legal results of Hegel's employment of a conceptual apparatus and theoretical constructs in the dialectical investigation of the objective spirit. Therefore, it is valid to single out two aspects of the political content of Hegel's philosophy of law: the historically concrete political views developed by Hegel in his Philosophy of Right; and the totality of politically meaningful propositions deriving from his application of dialectics to the sphere of politics — which we here call Hegel's dialectics of politics. (shrink)

Издание адресовано научным работникам, преподавателям, студентам и аспирантам, а также практикам, интересующимся вопросами философии.

Издание содержит: научное изучение времени и информации; философское изучение времени и информации; практическое применение знаний о времени и информации и др.

The proceedings of the Round Table on "Reason vs Post-Truth: Ontology, Axiology, Geopolitics".Authors of the proceedings:V.V. Mironov K.K. Momdzhyan A.V. Belokobylskyi A.P. Kozyrev O.A. Efremov M.V. Bratersky A.V. Pilko V.S. Levytskyy.

A t first glance you might not noorder, which afflicts about 0.5 percent of tice anything odd on meeting a American children. Neither researcher young boy with autism. But if had any knowledge of the other’s work, you try to talk to him, it will and yet by an uncanny coincidence each quickly become obvious that gave the syndrome the same name: autism, something is seriously wrong. He may not which derives from the Greek word autos, make eye contact with (...) you; instead he may meaning “self.” The name is apt, because avoid your gaze and fidget, rock his body the most conspicuous feature of the disorto and fro, or bang his head against the der is a withdrawal from social interacwall. More disconcerting, he may not be tion. More recently, doctors have adopted able to conduct anything remotely resemthe term “autism spectrum disorder” to bling a normal conversation. Even though make it clear that the illness has many rehe can experience emotions such as fear, lated variants that range widely in severity rage and pleasure, he may lack genuine but share some characteristic symptoms. empathy for other people and be oblivious Ever since autism was identified, reto subtle social cues that most children searchers have struggled to determine would pick up effortlessly. what causes it. Scientists know that sus- In the 1940s two physicians—Americeptibility to autism is inherited, although.. (shrink)

In recent years, very little that is new has happened in that branch of particle physics which investigates the structure of particles. In an earlier period, certain doubts had existed about the applicability of quantum electrodynamics at distances of the order of 10-14 cm. Experiments that are universally known, in which pairs of electrons and mu-mesons arose, contradicted the theory somewhat. Later, however, it became clear that all this was a consequence of certain methodological inaccuracies.

Simulation and Similarity is a novel and comprehensive account of, in first place, models and modeling. The author’s writing is exceptionally clear and intelligible. Simulation is referred to in the book only once, where it is defined as a kind of numerical analysis involving “computing the behavior of the model using a particular set of initial conditions” (82). Modeling, which is defined as “the indirect study of real-world systems via the construction and analysis of models” (4), appears to be the (...) primary focus of this book. This emphasis seems legitimate because the modeling practice precedes any simulation and is the key to its understanding as well.Chapter 2 “Three kinds of models” presents an account of the following kinds of models: concrete models (San Francisco Bay model being an example), mathematical models (Lottka–Volterra model of predation as an example), and computational models (illustrated by Schelling’s segregation model). First model example is a hydraulic one; the .. (shrink)